DNA METHYLATION IN BIPOLAR DISORDER

Bipolar disorder affects 1% of the population and is a severe mental illness accompanied with recurrent episodes of mania and depression with suicidal tendency's.In bipolar disorder, lymphoblastoid cells of individuals have altered signal transduction systems pathiophysiology studies, have proven a major role of DNA METHYLATION and histone acethylation.In the journal peptidylprolyl isomerase E-like (PPIEL) involved in the specific neuronal function ike dopamine neuro transmission or neuron endocrine systems which shows aberrant Dna methyalation and through MS-RDA (methylation sensitive representational difference analysis technique, four aberrant methylation regions obtained,were analyzed further by pyrosequencing and the analyzed CpG site with respect to PPIEL showed significant DNA methylaytion and gene expression.